Micro and Nanodevices Laboratory

Microfluidics:

• Organs on chips: gut on a chip, lung on a chip. Our group focuses on use of new materials, that would allow to reduce small molecule absorption and would ensure anaerobic conditions. Also we work on integration of sensors.
• Microfluidic devices for extracellular vesicle separation and concentration from biological samples for early cancer diagnostics.

Cell culturing and studies of biological processes takes place at partner organizations.

Additional to applications in biology we are developing microfluidic devices for synthesis of spider silk and studies of magnetic particles.

Photonics: research and development of devices based on organic materials such as Su-8, PMMS and other materials. Studies of light coupling to polymer waveguides.

By combining skills and knowledge in microfluidics and photonics we are developing label free biosensors for detection of cancer biomarkers.

Liquid crystal displays: development of thins films and pattern fabrication for high voltage liquid crystal and other custom displays. Characterization of optical and electrical properties. Displays are made in cooperation with industrial partner EuroLCDs.

Active projects:

European Regional Development Fund (LIAA administrated)

Mass-manufacturable gut on a chip device (2020-2022)

Optical gas sensor (2020-2022)

Latvian Council of Science

Microfluidic field flow fractionation for high throughput extra-cellular vesicle separation (2020-2022)

Postdoctoral

Microfluidic chip with multidetection module for evaluation of nPEF induced gene expression (2021-2023)

Towards a Universal Lab-on-Chip Sensor from a Single Graphene Sheet: from Photodetection to Biosensing (2021-2023)

Accomplished projects:

Latvian Council of Science

Research of extracellular vesicle content from gut microbiome and its’ role in cancer development by applying gut on chip system (2020-2021)

National Research Program

Development of new therapeutic and prophylactic treatments against covid-19 and coronaviruses (2020)

Latvia:

• Latvian Biomedical Research and Study Centre (Dr.A.Abols and prof .A.Line)
• Latvian Institute of Organic Synthesis (Dr. K.Jaudzems)
• University of Latvia,
  • Institute of chemical physics
  • Laboratory of Magnetic Soft Materials (Dr. G.Kitenbergs)
  • Laser center (Dr. A.Berzins)
• EuroLCDs
• LightSpace Technologies

Sweden:

• KTH (A.Herland)
• RISE (Dr.Q.Wang)

2023

• Bajo-Santos, C.; Priedols, M.; Kaukis, P.; Paidere, G.; Gerulis-Bergmanis, R.; Mozolevskis, G.; Abols, A.; Rimsa, R. Extracellular Vesicles Isolation from Large Volume Samples Using a Polydimethylsiloxane-Free Microfluidic Device. Int. J. Mol. Sci. 2023, 24, 7971. https://doi.org/10.3390/ijms24097971
• A.Berzins, J.Smits, A.Petruhins, R.Rimsa, G.Mozolevskis, M.Zubkins, I.Fescenko. NV microscopy of thermally controlled stresses caused by thin CrO films, Optics Express, 2023
• Priedols, M.; Paidere, G.; Santos, C.B.; Miscenko, A.; Bergmanis, R.G.; Spule, A.; Bekere, B.; Mozolevskis, G.; Abols, A.; Rimsa, R. Bifurcated Asymmetric Field Flow Fractionation of Nanoparticles in PDMS-Free Microfluidic Devices for Applications in Label-Free Extracellular Vesicle Separation. Polymers 2023, 15, 789 https://doi.org/10.3390/polym15040789
• Letko, E.; Bundulis, A.; Mozolevskis, G. Theoretical Development of Polymer-Based Integrated Lossy-Mode Resonance Sensor for Photonic Integrated Circuits. Photonics 2022, 9, 764. https://doi.org/10.3390/photonics9100764

2022

• Jasulaneca L, Meija R, Kauranens E, Sondors R, Andzane J, Rimsa R, Mozolevskis G, Erts D. Cryogenic nanoelectromechanical switch enabled by Bi₂Se₃ nanoribbons. Mater Sci Eng B Solid State Adv Technol 2022; 275.
• Kavaliauskaitė, J.; Kazlauskaitė, A.; Lazutka, J.R.; Mozolevskis, G.; Stirkė, A. Pulsed Electric Fields Alter Expression of NF-κB Promoter-Controlled Gene. Int. J. Mol. Sci. 2022, 23, 451.
• Kunakova, G.; Kauranens, E.; Niherysh, K.; Bechelany, M.; Smits, K.; Mozolevskis, G.; Bauch, T.; Lombardi, F.; Erts, D. Magnetotransport Studies of Encapsulated Topological Insulator Bi2Se3 Nanoribbons. Nanomaterials 2022, 12, 768.

2021

• R.Rimsa, A.Galvanovskis, J.Plume, F.Rumnieks, K.Grindulis, G.Paidere, S.Erentraute, G.Mozolevskis and A.Abols. Lung on a Chip Development from Off-Stoichiometry Thiol–Ene Polymer, Micromachines 2021, 12(5), 546.
• Fu, Y.; Yager, T.; Chikvaidze, G.; Iyer, S.; Wang, Q. Time-Resolved FDTD and Experimental FTIR Study of Gold Micropatch Arrays for Wavelength-Selective Mid-Infrared Optical Coupling. Sensors 2021, 21, 5203.